Chronic pain is one of the leading causes of disability worldwide and significantly affects patients' quality of life. Non-steroidal anti-inflammatory drugs (NSAIDs) remain the first-line pharmacological treatment for inflammatory and musculoskeletal pain due to their analgesic and anti-inflammatory effects. However, prolonged NSAID therapy is associated with gastrointestinal toxicity, cardiovascular complications, renal impairment, frequent dosing, and poor patient compliance. These limitations have stimulated the development of advanced drug delivery systems that provide sustained, targeted, and controlled drug release. Recent research highlights the potential of biodegradable microspheres, nanoparticles, liposomes, hydrogels, injectable depot formulations, and nanofibers to enhance therapeutic efficacy while minimising systemic adverse effects. This review summarises the limitations of conventional NSAID therapy, discusses recent advances in novel delivery platforms, and compares conventional and emerging treatment strategies for chronic pain. These innovations are expected to improve patient adherence and support personalised pain management.
Chronic pain, NSAIDs, Microspheres, Injectable depot, Sustained release, Nanoparticles, Drug delivery, Biodegradable polymers.
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.